Effect of CA4P treatment alone or in combination with Avastin on renal cell carcinoma (Caki-1) xenograft growth. CA4P (100 mg/kg) was given Mondays, Wednesdays, and Fridays for 2 weeks. Avastin treatment (2 mg/kg) was administered daily (Monday through Friday) for 2 weeks. Data shown are a) the growth of the median tumors and b) the median, 75th, and 90th percentiles of responses of tumors treated at a starting size of 200 mm3. Results in mice treated with combination therapy were significantly greater than those obtained in mice treated only with a single therapy (p<0.05, Wilcoxon rank sum test). Figure was modified from ().