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J Exp Zool B Mol Dev Evol. 2009 Jun 15;312B(4):343-50. doi: 10.1002/jez.b.21274.

Epithelial-specific requirement of FGFR2 signaling during tooth and palate development.

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1
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA.

Abstract

Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial-mesenchymal tissue interaction. We have generated epithelial-specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (Fgfr2) to investigate the function of FGF signaling during craniofacial development. K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of K14-Cre;Fgfr2(fl/fl) mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development.

PMID:
19235875
PMCID:
PMC2896559
DOI:
10.1002/jez.b.21274
[Indexed for MEDLINE]
Free PMC Article
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