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J Autism Dev Disord. 2009 Jul;39(7):1079-86. doi: 10.1007/s10803-009-0707-6. Epub 2009 Feb 21.

Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder.

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1
Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA. nkleinha@u.washington.edu

Abstract

Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.

PMID:
19234776
PMCID:
PMC4114770
DOI:
10.1007/s10803-009-0707-6
[Indexed for MEDLINE]
Free PMC Article
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