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Can J Physiol Pharmacol. 2009 Feb;87(2):130-6. doi: 10.1139/Y08-107.

Polymorphonuclear blood leukocytes and restenosis after intracoronary implantation of drug-eluting stents.

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Laboratory of Stem Cells and Department of Atherosclerosis, Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street, 15A, Moscow 121 552, Russia.


Peripheral blood contents of osteonectin-positive progenitor cells and polymorphonuclear granulocytes were examined by flow cytometry in 38 patients after myocardial revascularisation with drug-eluting stents. Repeat coronary angiography performed 6-12 months after stent implantation revealed in-stent restenosis in 15 patients and its absence in 23 patients. The plasma levels of osteonectin-positive progenitor cells, neutrophils, and basophils did not differ in patients with and without restenosis. Eosinophil blood levels in patients with and without restenosis were 262+/-68 and 124+/-67 cells/microL (mean+/-SD, p<0.001), respectively. Only one of 19 patients (5%) with eosinophil content lower than the distribution median for the entire group developed restenosis, whereas in the group with eosinophil contents higher than the median (n=19) restenosis occurred in 14 patients (74%, p<0.001). Our findings suggest that the frequency of restenoses after stenting is related to high peripheral blood eosinophil content.

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