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Fam Pract. 2009 Apr;26(2):88-95. doi: 10.1093/fampra/cmp006. Epub 2009 Feb 20.

Statin use and its association with musculoskeletal symptoms--a cross-sectional study in primary care settings.

Author information

1
Division of General Medicine, University of Tübingen, Tübingen, Germany. dirk.mosshammer@uni-tuebingen.de

Abstract

INTRODUCTION:

Musculoskeletal complaints are very common in primary care settings. Lipid-lowering drugs are one of several causes of musculoskeletal symptoms. However, data showing an association of lipid-lowering drug therapy and increased odds of musculoskeletal complaints in primary care patients are lacking.

OBJECTIVE:

To investigate the association between statin use and the reporting of muscular complaints by patients and simultaneously control for several known factors of musculoskeletal complaints.

METHODS:

In a cross-sectional study with 1031 consecutive patients (>50 years of age) in 26 offices of GPs, two investigators collected the data from the office files and by interviewing the patients. A logistic regression model was used to identify variables affecting the odds of muscular symptoms.

RESULTS:

The prevalence of lipid-lowering drug prescription was 23% (n = 239) and that of muscular complaints was 40% (n = 411). In all, 44% (n = 106) of the patients with lipid-lowering drug prescription had muscular complaints compared to 39% (n = 305) of the patients without lipid-lowering drug therapy. Statin prescription and 10 variables remained in the final model. Statin prescription is associated with a 1.5-fold odds of musculoskeletal complaints compared to non-prescription {odds ratio [OR] = 1.5 [95% confidence interval (CI), 1.1-2.0], P = 0.02}.

CONCLUSION:

Having a statin prescription appears to be an independent factor associated with musculoskeletal symptoms in primary care settings. Statin use may be more often associated with musculoskeletal complaints than previously assumed.

PMID:
19233960
DOI:
10.1093/fampra/cmp006
[Indexed for MEDLINE]

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