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Curr Opin Biotechnol. 2009 Feb;20(1):45-53. doi: 10.1016/j.copbio.2009.01.007. Epub 2009 Feb 23.

Advances in bioluminescence imaging of live animal models.

Author information

1
Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. dothagerr@mir.wustl.edu

Abstract

Many of the obligate steps of physiology and disease are dynamic in time and space, and thus, end-point assays do not always provide a full understanding of these processes. Comprehensive understanding of the functional complexity of protein interactions and cell trafficking requires mapping of cellular and molecular function within complex systems over biologically relevant time scales. New approaches to bioluminescence imaging of cell migration, signaling pathways, drug action, and interacting protein partners in vivo allow the study of biology and disease within the context of living animals.

PMID:
19233638
PMCID:
PMC2680462
DOI:
10.1016/j.copbio.2009.01.007
[Indexed for MEDLINE]
Free PMC Article

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