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Aesthet Surg J. 2009 Jan-Feb;29(1):40-6. doi: 10.1016/j.asj.2008.11.006.

Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids.

Author information

1
sDepartment of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. pd2@gunet.georgetown.edu

Abstract

BACKGROUND:

Keloids are a common problem with significant recurrence rates despite intralesional steroid treatment and multimodal therapy.

OBJECTIVE:

The purpose of this study was to evaluate the efficacy of using a 5-fluorouracil (5-FU)/steroid mixture to treat keloids over the past 7 years, comparing the results with use of steroid treatment alone.

METHODS:

Patient charts from 1999 to 2006 were reviewed. Patients were stratified into 3 groups: (1) 5-FU/steroid without excision; (2) 5-FU/steroid with excision; and (3) steroid treatment with excision. The percentage of lesion size reduction and symptoms were evaluated.

RESULTS:

A total of 102 keloids were identified in a retrospective review. Patients who underwent the 5-FU/steroid combination with excision had a 92% average reduction in lesion size compared with 73% in the group of patients who did not receive 5-FU. Patients who received 5-FU/steroid without excision had an average lesion size reduction of 81%. Differences in complication rates were not statistically significant.

CONCLUSIONS:

Combination 5-FU/triamcinolone is superior to intralesional steroid therapy in the treatment of keloids.

PMID:
19233005
DOI:
10.1016/j.asj.2008.11.006
[Indexed for MEDLINE]

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