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Eur J Med Chem. 2009 Jul;44(7):3020-6. doi: 10.1016/j.ejmech.2008.12.027. Epub 2009 Jan 19.

Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts.

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Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, Athens, Greece.


In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity.

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