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Int J Gynaecol Obstet. 2009 May;105(2):158-61. doi: 10.1016/j.ijgo.2009.01.016. Epub 2009 Feb 20.

Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome.

Author information

1
Fatemeh College of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

OBJECTIVE:

To compare the effects of dydrogesterone and calcium plus vitamin D in women with severe premenstrual syndrome (PMS).

METHOD:

In this randomized, double-blind, placebo-controlled study, 180 Shiraz University students with PMS used questionnaires daily to rate their symptoms for 2 menstrual cycles. Then, the students were randomly assigned to take a tablet containing either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of the cycle for 2 more cycles, and to use the same questionnaires during the intervention cycles. The collected data were then analyzed by repeated-measurement design and multilevel modeling tests.

RESULT:

Treatment with dydrogesterone or calcium plus vitamin D decreased symptom severity in a similar way (by 4.64% and 4.20%, respectively) and placebo was associated with a 3.42% decrease.

CONCLUSION:

Treatment with dydrogesterone or calcium plus vitamin D had a similar effect on symptom severity in women with PMS.

PMID:
19232611
DOI:
10.1016/j.ijgo.2009.01.016
[Indexed for MEDLINE]

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