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Int J Gynaecol Obstet. 2009 May;105(2):131-5. doi: 10.1016/j.ijgo.2008.12.019. Epub 2009 Feb 20.

Effects of visceral peritoneal closure on scar formation at cesarean delivery.

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Department of Obstetrics and Gynecology, Santa Maria Hospital, Bari, Italy.



To determine the effect of closure or non-closure of the visceral peritoneum at cesarean delivery on uterine scar formation assessed at repeat cesarean delivery.


Women undergoing initial cesarean delivery were allocated into 2 groups: group 1 underwent visceral peritoneal closure, while in group 2 the visceral peritoneum was not closed. At repeat cesarean delivery 4 specimens from the initial uterine scar were collected and assessed by light microscopy and scanning electron microscopy.


In group 1, 57% of women had adhesions compared with 20.6% in group 2 (P<0.05). Light microscopy revealed reactive mesothelial hyperplasia (51.8% vs 13.7%), submesothelial fibrosis (48.1% vs 6.8%), and neoangiogenesis of mesothelial stroma (44.4% vs 12%) in group 1 and group 2 patients, respectively (P<0.05). Scanning electron microscopy showed more patients with pericytes on the surface of microvessels in group 1 compared with group 2 (26.3+/-1.4 vs 11.5+/-1.1 patients; P<0.05).


Closure of the visceral peritoneum at cesarean delivery may produce an inflammatory reaction and adhesions, evidenced by reactive and regenerative mesothelial hyperplasia and submesothelial fibrosis.

[Indexed for MEDLINE]

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