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Fertil Steril. 2010 May 1;93(7):2125-9. doi: 10.1016/j.fertnstert.2009.01.072. Epub 2009 Feb 15.

Evaluation of high-sensitivity C-reactive protein in comparison with C-reactive protein as biochemical serum markers in women with endometriosis.

Author information

1
Department of Obstetrics and Gynecology, Erlangen University Hospital, D-91054 Erlangen, Germany.

Abstract

OBJECTIVE:

To compare high-sensitivity C-reactive protein (hs-CRP) with CRP as a soluble serum marker for the diagnosis of women with endometriosis.

DESIGN:

Prospective nonrandomized controlled trial (Canadian Task Force classification II-1).

SETTING:

University hospital.

PATIENT(S):

Eighty-two women were laparoscopically evaluated. No endometriosis was diagnosed in 34 women (the non-E group). Endometriosis was confirmed by histology in 48 women (the E group). Eighty-two women did not undergo laparoscopic evaluation (the unknown-E group). Afterward, the women were staged according to the revised American Society for Reproductive Medicine criteria (r-ASRM).

INTERVENTION(S):

CRP and hs-CRP were measured initially before laparoscopy.

MAIN OUTCOME MEASURE(S):

The hs-CRP and CRP levels and the correlation of those parameters with the stage of the disease.

RESULT(S):

There was a trend toward higher CRP levels and higher hs-CRP levels in the E group, while the lowest levels of both markers were found in the non-E group. There was a significantly lower hs-CRP level in the non-E group in comparison with the CRP level in this group. No differences between the different stages of the disease were found with either marker.

CONCLUSION(S):

Measurement of the two markers did not appear to be advantageous for the diagnosis of endometriosis independent of the stage of the disease. Nevertheless, a very low hs-CRP level might serve as a marker for an absence of endometriosis.

[Indexed for MEDLINE]

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