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Adv Immunol. 2009;101:81-121. doi: 10.1016/S0065-2776(08)01003-1.

Biology of the eosinophil.

Author information

1
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.

Abstract

In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the eosinophil, by placing it in the context of innate and adaptive immune responses. Eosinophils have a unique contribution in initiating inflammatory and adaptive responses, due to their bidirectional interactions with dendritic cells and T cells, as well as their large panel of secreted cytokines and soluble mediators. The mechanisms and consequences of eosinophil responses in experimental inflammatory models and human diseases are discussed.

PMID:
19231593
PMCID:
PMC4109275
DOI:
10.1016/S0065-2776(08)01003-1
[Indexed for MEDLINE]
Free PMC Article

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