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DNA Repair (Amst). 2009 Apr 5;8(4):536-43. doi: 10.1016/j.dnarep.2009.01.011. Epub 2009 Feb 23.

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases.

Author information

1
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10065, United States.

Abstract

Eukaryotic cells repair ultraviolet light (UV)- and chemical carcinogen-induced DNA strand-distorting damage through the nucleotide excision repair (NER) pathway. Concurrent activation of the DNA damage checkpoints is also required to arrest the cell cycle and allow time for NER action. Recent studies uncovered critical roles for ubiquitin-mediated post-translational modifications in controlling both NER and checkpoint functions. In this review, we will discuss recent progress in delineating the roles of cullin-RING E3 ubiquitin ligases in orchestrating the cellular DNA damage response through ubiquitination of NER factors, histones, and checkpoint effectors.

PMID:
19231300
PMCID:
PMC2858918
DOI:
10.1016/j.dnarep.2009.01.011
[Indexed for MEDLINE]
Free PMC Article

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