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Curr Opin Immunol. 2009 Feb;21(1):63-7. doi: 10.1016/j.coi.2009.01.011. Epub 2009 Feb 21.

Iron in innate immunity: starve the invaders.

Author information

1
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, United States. tganz@mednet.ucla.edu

Abstract

Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron availability to microbial invaders. Some microbes have evolved effective countermeasures that blunt the effect of iron restriction. Recent epidemiologic studies have highlighted the potentiating effect of iron on microbial infections. Laboratory studies have focused on specific immune mechanisms that mediate iron withholding from microbes constitutively and in response to infections. Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections.

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PMID:
19231148
PMCID:
PMC2668730
DOI:
10.1016/j.coi.2009.01.011
[Indexed for MEDLINE]
Free PMC Article

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