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Vaccine. 2008 Sep 12;26 Suppl 4:D49-53.

The biology of influenza viruses.

Author information

1
Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA.

Abstract

The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure ofthe influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in viruses able to evade the long-term adaptive immune responses in many hosts.

PMID:
19230160
PMCID:
PMC3074182
[Indexed for MEDLINE]
Free PMC Article

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