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Haematologica. 2009 Apr;94(4):536-41. doi: 10.3324/haematol.2008.002741. Epub 2009 Feb 19.

Cord blood stem cells for hematopoietic stem cell transplantation in the UK: how big should the bank be?

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  • 1Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW32QG, UK.

Abstract

BACKGROUND:

A stored cord blood donation may be a valuable source of hemopoietic stem cells for allogeneic transplantation when a matched sibling donor is not available. We carried out a study to define the optimal size of a national cord blood bank for the UK.

DESIGN AND METHODS:

We calculated the actual numbers of possible donors and the chance of finding at least one donor for 2,000 unselected and for 722 non-North Western European patients for whom searches had been initiated as a function of three levels of HLA matching (4, 5 and 6 out of 6 alleles by HLA-A, -B low and -DRB1 high resolution HLA typing) according to various donor bank sizes.

RESULTS:

With a bank size of 50,000, 80% of patients will have at least one donor unit available at the 5 out of 6 HLA allele match level (median 9 donors per patient), and 98% will have at least one donor at the 4 out of 6 allele match level (median 261). Doubling the size of the bank yields at least one donor for only an additional 6% of patients at the 5 of 6 allele match level. Moreover, for non-North Western European patients a 50,000 unit bank provides a donor for 50% at the 5 allele match level, and for 96% at the 4 allele match level.

CONCLUSIONS:

A bank containing 50,000 units is optimal for the UK and larger banks would only marginally increase the chance of finding suitable units.

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PMID:
19229051
PMCID:
PMC2663617
DOI:
10.3324/haematol.2008.002741
[PubMed - indexed for MEDLINE]
Free PMC Article
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