Sorghum holepense is an extremely wide spread species, being met in many European, Asian, American and African countries and covering approximately 1/3 of the land cultivated with fields crops, grapevine, fruit trees and vegetables. In Romania, Sorghum halepense is present in almost all the country, invading in hoed-plants ad vegetable crops as well as grapevine and fruit-tree plantations. The losses caused by Sorghum halepense are enormous; in case of maize and sugar beet crops, these losses reach and extremely high rate of 30-70%. For these reasons, at the University of Agricultural Sciences and Veterinary Medicine, Timisoara, city in western part of Romania, a study was made having as objects the latest herbicides synthesized in the world: Equip--which contains 22.5 g/l foramsulfuron + 22.5 g/l isoxadifen-ethyl (safener); Mais-Ter--which contains 300 g/kg foramsulfuron + 10 g/kg iodosulfuron-methyl sodium + 300 g/kg isoxadifen-ethyl (safener); Terano--which contains 600 g/kg flufenacet + 25 g/kg metasulfuron; Mistral (standard)--which contains 40 g/l nicosulfuron. Each of these herbicides (in commercial form) was applied in four doses. The best results in the control of Sorghum halepense obtained by applying the Mistral herbicide. In second place from the point of you of its efficacy came the herbicide Mais-Ter and third place the herbicide Equip. The lowest degree of efficacy was recorded by the herbicide Terano. The grain yield in case of maize crops treated with before mentioned herbicides was in strict correlation with the efficacy of the herbicides and especially with the dose applied per hectare.