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Mol Biosyst. 2009 Mar;5(3):224-34. doi: 10.1039/b819850k. Epub 2009 Jan 16.

High-density peptide arrays.

Author information

1
German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany. f.breitling@dkfz.de

Abstract

Arrays promise to advance biology by allowing parallel screening for many different binding partners. Meanwhile, lithographic methods enable combinatorial synthesis of > 50,000 oligonucleotides per cm(2), an advance that has revolutionized the whole field of genomics. A similar development is expected for the field of proteomics, provided that affordable, very high-density peptide arrays are available. However, peptide arrays lag behind oligonucleotide arrays. This review discusses recent developments in the field with an emphasis on methods that lead to very high-density peptide arrays.

PMID:
19225611
DOI:
10.1039/b819850k
[Indexed for MEDLINE]

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