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EMBO J. 2009 Feb 18;28(4):313-4. doi: 10.1038/emboj.2008.303.

Bypass specialists operate together.

Author information

1
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.

Abstract

New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.

PMID:
19225445
PMCID:
PMC2646159
DOI:
10.1038/emboj.2008.303
[Indexed for MEDLINE]
Free PMC Article

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