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EMBO J. 2009 Feb 18;28(4):309-10. doi: 10.1038/emboj.2008.301.

The type VI secretion system: a tubular story.

Author information

1
Division of Cell and Molecular Biology, Imperial College London, Centre for Molecular Microbiology and Infection, London, UK. a.filloux@imperial.ac.uk

Abstract

The molecular mechanism by which proteins are secreted in gram-negative bacteria is supported by nanomachines called type I to type VI secretion systems (T1SS to T6SS). Previous data suggested that the ClpV ATPase energizes the transport of Hcp and VgrG proteins through the T6SS secretion channel. The identification of a yet unknown tubular structure, which interacts with ClpV, adds another level of complexity and challenges our vision of the T6SS working model.

PMID:
19225443
PMCID:
PMC2646157
DOI:
10.1038/emboj.2008.301
[Indexed for MEDLINE]
Free PMC Article

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