Format

Send to

Choose Destination
Neuroscientist. 2009 Oct;15(5):477-88. doi: 10.1177/1073858408327808. Epub 2009 Feb 17.

Brain clocks: from the suprachiasmatic nuclei to a cerebral network.

Author information

1
Institute of Cellular and Integrative Neurosciences, Centre National dela Recherche Scientifique, University Louis Pasteur, Strasbourg, France.

Abstract

Circadian timing affects almost all life's processes. It not only dictates when we sleep, but also keeps every cell and tissue working under a tight temporal regimen. The daily variations of physiology and behavior are controlled by a highly complex system comprising of a master circadian clock in the suprachiasmatic nuclei (SCN) of the hypothalamus, extra-SCN cerebral clocks, and peripheral oscillators. Here are presented similarities and differences in the molecular mechanisms of the clock machinery between the primary SCN clock and extra-SCN brain clocks. Diversity of secondary clocks in the brain, their specific sensitivities to time-giving cues, as their differential coupling to the master SCN clock, may allow more plasticity in the ability of the circadian timing system to integrate a wide range of temporal information. Furthermore, it raises the possibility that pathophysiological alterations of internal timing that are deleterious for health may result from internal desynchronization within the network of cerebral clocks.

PMID:
19224887
DOI:
10.1177/1073858408327808
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center