Format

Send to

Choose Destination
Nature. 1991 Sep 26;353(6342):321-5.

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation.

Author information

1
Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, Massachusetts.

Abstract

X-ray crystallography reveals electron density in the antigen-binding site of HLA-B27 that is an interpretable image of nonameric peptides in a largely extended conformation. Clear density exists for the main chain and several side chains and is consistent with the sequence of 11 nonameric self-peptides eluted from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the amino and carboxyl termini of the peptide.

PMID:
1922337
DOI:
10.1038/353321a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center