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J Ren Care. 2009 Mar;35 Suppl 1:34-8. doi: 10.1111/j.1755-6686.2009.00050.x.

Pathogenesis of bone and mineral related disorders in chronic kidney disease: key role of hyperphosphatemia.

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Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto Reina Sofía de Investigación, REDinREN del ISCIII, Universidad de Oviedo, Oviedo, Asturias, Spain.


This paper reviews the pathogenesis of hyperphosphataemia and its role in the regulation of parathyroid hormone synthesis and parathyroid cell proliferation in chronic kidney disease. The association between hyperphosphaemia and vascular calcification, and the interventions that can be used to control plasma phosphate are also discussed.

[Indexed for MEDLINE]

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