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FEMS Microbiol Lett. 2009 Apr;293(1):130-4. doi: 10.1111/j.1574-6968.2009.01515.x. Epub 2009 Feb 12.

High environmental iron concentrations stimulate adhesion and invasive growth of Schizosaccharomyces pombe.

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1
Department of Cell Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.

Abstract

We have found that a high iron concentration in solid complete cultivation medium potentiates cell-cell and cell-surface adhesion of the fission yeast Schizosaccharomyces pombe. Spotted giant colonies grown on iron-rich media were found to be more compact and more resistant to washing than those grown on plates with a standard iron content. Furthermore, we have documented that excess environmental iron stimulates the invasive growth of S. pombe (and Saccharomyces cerevisiae). Three-dimensional, branched, washing-resistant structures composed mostly of elongated, but separate fission yeast cells, were formed within the solid agar medium. The degree of both adhesion and invasion displayed a specific, iron concentration-dependent response. Our results suggest a novel link between iron availability and the intensively studied and important fungal virulence factors, adhesion and invasion.

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