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Am J Chin Med. 2009;37(1):159-67.

Estrogen activities and the cellular effects of natural progesterone from wild yam extract in mcf-7 human breast cancer cells.

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1
Department of Bioscience and Biotechnolgy, College of Engineering, Institute of Biotechnology, Sejong University, Seoul, Korea.

Abstract

We studied the estrogenic activity and cellular effect of wild yam extract in MCF-7 human breast cancer cells. The extract increased the activity of the progesterone receptor and pS2 genes at the mRNA levels in human breast cancer MCF-7 cells, although the effects were not as prominent as those of 17beta-estradiol (E(2)). Western blot analysis showed that the level of estrogen receptor alpha protein was down-regulated after treatment with E(2) or wild yam extract. Wild yam extract also inhibited proliferation of MCF-7 cells. These data indicate that wild yam extract acts as a weak phytoestrogen and protects against proliferation in human breast carcinoma MCF-7 cells.

PMID:
19222119
DOI:
10.1142/S0192415X09006746
[Indexed for MEDLINE]
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