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Angew Chem Int Ed Engl. 2009;48(23):4134-7. doi: 10.1002/anie.200806000.

Icosahedral DNA nanocapsules by modular assembly.

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1
National Centre for Biological Sciences, TIFR, GKVK, Bellary Road, Bangalore, 560 065, India.

Abstract

It's a trap! DNA polyhedra formed through molecular self-assembly may function as nanocapsules for the targeted delivery of encapsulated entities. This functional aspect was demonstrated for the most complex DNA-based platonic solid: During the stepwise amalgamation of discrete polyhedra to form icosahedra, gold nanoparticles (GNPs) were encapsulated from solution (see illustration and TEM image of icosahedral cages containing GNPs).

PMID:
19222079
DOI:
10.1002/anie.200806000
[Indexed for MEDLINE]
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