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Angew Chem Int Ed Engl. 2009;48(13):2321-4. doi: 10.1002/anie.200805666.

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

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1
Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174, USA.

Abstract

Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation (see figure).

PMID:
19222062
DOI:
10.1002/anie.200805666
[Indexed for MEDLINE]
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