Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2009 Mar 15;8(6):832-7. Epub 2009 Mar 16.

Cell "circadian" cycle: new role for mammalian core clock genes.

Author information

1
Developmental Neurobiology Unit, Center for Cellular and Molecular Neurobiology, University of Liège, Liège, Belgium.

Abstract

In mammals, 24 hours rhythms are organized as a biochemical network of molecular clocks that are operative in all tissues, with the master clock residing in the hypothalamic suprachiasmatic nucleus (SCN). The core pacemakers of these clocks consist of auto-regulatory transcriptional/post-transcriptional feedback loops. Several lines of evidence suggest the existence of a crosstalk between molecules that are responsible for the generation of circadian rhythms and molecules that control the cell cycle progression. In addition, highly specialized cell cycle checkpoints involved in DNA repair after damage seem also, at least in part, mediated by clock proteins. Recent studies have also highlighted a putative connection between clock protein dysfunction and cancer progression. This review discusses the intimate relation that exists between cell cycle progression and components of the circadian machinery.

PMID:
19221497
DOI:
10.4161/cc.8.6.7869
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center