Send to

Choose Destination
See comment in PubMed Commons below
Philos Trans A Math Phys Eng Sci. 2009 Mar 28;367(1891):1145-61. doi: 10.1098/rsta.2008.0255.

Onset of polyspike complexes in a mean-field model of human electroencephalography and its application to absence epilepsy.

Author information

  • 1Department of Engineering Mathematics, University of Bristol, Bristol BS8 1TR, UK.


In this paper, we introduce a modification of a mean-field model used to describe the brain's electrical activity as recorded via electroencephalography (EEG). The focus of the present study is to understand the mechanisms giving rise to the dynamics observed during absence epilepsy, one of the classical generalized syndromes. A systematic study of the data from a number of different subjects with absence epilepsy demonstrates a wide variety of dynamical phenomena in the recorded EEG. In addition to the classical spike and wave activity, there may be polyspike and wave, wave spike or even no discernible spike-wave onset during seizure events. The model we introduce is able to capture all of these different phenomena and we describe the bifurcations giving rise to these different types of seizure activity. We argue that such a model may provide a useful clinical tool for classifying different subclasses of absence epilepsy.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center