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Cell Host Microbe. 2009 Feb 19;5(2):107-9. doi: 10.1016/j.chom.2009.01.002.

Shigella targets the mitochondrial checkpoint of programmed necrosis.

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1
INSERM, U848, Villejuif, France.

Abstract

In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which determines the fate of infected cells.

PMID:
19218080
DOI:
10.1016/j.chom.2009.01.002
[Indexed for MEDLINE]
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