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Clin Chim Acta. 2009 May;403(1-2):139-41. doi: 10.1016/j.cca.2009.02.004. Epub 2009 Feb 13.

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach.

Author information

1
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. rzee@rics.bwh.harvard.edu

Abstract

BACKGROUND:

Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce.

METHODS:

Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol, among 337 white males who subsequently developed an incident myocardial infarction (MI), and among an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls).

RESULTS:

The mean follow-up time since randomization was 3.85 y. The T/S ratio was inversely correlated with age in the controls (R=-0.114; p=0.036). The log(e)-transformed T/S ratios were significantly smaller in the MI cases (3.41+/-0.63) than the MI controls (3.52+/-0.78) (p=0.01). In a multi-variable adjusted analysis, decreased T/S ratio was significantly associated with risk of MI (odds ratio=1.621; 95%CI=1.140-2.304; p=0.007).

CONCLUSIONS:

The present investigation has shown an association of telomere length shortening with increased risk of incident myocardial infarction, further suggesting the importance of telomere biology in atherogenesis.

PMID:
19217888
PMCID:
PMC2752372
DOI:
10.1016/j.cca.2009.02.004
[Indexed for MEDLINE]
Free PMC Article

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