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J Allergy Clin Immunol. 2009 Apr;123(4):763-9. doi: 10.1016/j.jaci.2008.12.013. Epub 2009 Feb 13.

Multiallergen immunotherapy for allergic rhinitis and asthma.

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1
Department of Medicine, National Jewish Health, Denver, CO 80206, USA. nelsonh@njc.org

Abstract

The English and non-English language literature on allergen immunotherapy was reviewed for studies simultaneously using 2 or more distinct allergen extracts in either subcutaneous or sublingual immunotherapy. Thirteen studies were identified, 11 using subcutaneous injections, 1 using sublingual administration, and 1 using both. In studies with adequate information, administration of 2 extracts by means of either subcutaneous immunotherapy or sublingual immunotherapy was effective. In studies using multiple allergens, 3 studies showed clear efficacy, whereas in the other 2 studies, lack of efficacy might have been due to inadequate doses of extract or omission of clinically relevant allergens in the treatment regimen. It is concluded that simultaneous administration of more than 1 allergen extract is clinically effective. However, more studies are needed, particularly with more than 2 allergen extracts and with sublingual administration.

PMID:
19217653
DOI:
10.1016/j.jaci.2008.12.013
[Indexed for MEDLINE]
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