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Endocrinol Metab Clin North Am. 2009 Mar;38(1):79-97. doi: 10.1016/j.ecl.2008.11.007.

Lowering low-density lipoprotein cholesterol: statins, ezetimibe, bile acid sequestrants, and combinations: comparative efficacy and safety.

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1
Endocrine Unit, University of Rochester, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA.

Abstract

Statins, ezetimibe, and bile acid-binding resins can be used individually or in combination for lowering low-density lipoprotein cholesterol (LDL-C) levels. Statins are the most potent drugs for lowering LDL-C and are well tolerated in most patients. The addition of a bile acid sequestrant or ezetimibe to a statin produces additional LDL-C reduction allowing many patients to reach LDL-C targets. This article discusses the efficacy and safety of available statins, bile acid sequestrants, and ezetimibe in the treatment of hyperlipidemia.

PMID:
19217513
DOI:
10.1016/j.ecl.2008.11.007
[Indexed for MEDLINE]
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