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Dev Cell. 2009 Feb;16(2):161-2. doi: 10.1016/j.devcel.2009.01.020.

Fibroblasts inform the heart: control of cardiomyocyte cycling and size by age-dependent paracrine signals.

Abstract

Within the developing and adult heart, the fibroblast is often dismissed as merely a structural element, important just to mechanical integrity or to scarring when excessive in disease. Ieda et al. in this issue of Developmental Cell now report an essential program of paracrine factor production in cardiac fibroblasts that controls heart muscle cell growth, driving cycling or enlargement depending on the fibroblasts' developmental stage.

PMID:
19217417
DOI:
10.1016/j.devcel.2009.01.020
[Indexed for MEDLINE]
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