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Diagn Cytopathol. 2009 Jun;37(6):450-4. doi: 10.1002/dc.21025.

Psammoma bodies in cervical smear in association with keratinizing squamous cell carcinoma of cervix: a case report.

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Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.


The presence of psammoma bodies (PBs) in cervical smears is a rare finding. These structures have been identified in association with a wide range of benign and malignant conditions within the female genital tract. PBs in cervical smears have usually been associated with malignant serous epithelial ovarian tumors. However, many PBs associated with atypical squamous cells were detected in cervical smears of an 83-year-old woman with complaint of postmenopausal bleeding. Colposcopic examination revealed an ulceroinfiltrative growth in the cervix. Histological examination of the biopsy specimen from the growth revealed keratinizing squamous cell carcinoma with multiple and singly arranged PBs. This report suggests that cytologists should aware of the possibilities, on finding PBs associated with atypical cells in cervical specimens and report the cases accordingly.

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