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J Laryngol Otol. 2009 Aug;123(8):880-4. doi: 10.1017/S0022215109004617. Epub 2009 Feb 16.

Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2.

Author information

1
*Department of Otolaryngology Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, Massachusetts, USA.

Abstract

OBJECTIVE:

Skin cancer is the most common cancer, and often occurs in the head and neck region. This study aimed to investigate whether a combination of inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase, applied via a microemulsion delivery system, would be effective in topically inhibiting skin carcinogenesis.

STUDY DESIGN:

Randomised animal study.

METHODS:

Twenty-four nude mice were intradermally inoculated with carcinoma cells and then divided into three groups (eight animals each): group one received no treatment; group two received celecoxib alone; and group three received a combination of zileuton and celecoxib. Tumour incidence and growth were measured for 14 days.

RESULTS:

Both treatments significantly delayed the onset and development of tumours. However, the combined treatment had the best response (p < 0.01).

CONCLUSION:

The results clearly showed that topical treatment with either celecoxib alone or celecoxib plus zileuton significantly inhibited skin carcinogenesis, and that a combination of both agents had the best results.

PMID:
19216818
PMCID:
PMC2714874
DOI:
10.1017/S0022215109004617
[Indexed for MEDLINE]
Free PMC Article

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