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Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(22):2678-82.

[Antiviral effect of epigallocatechin gallate (EGCG) on influenza A virus].

[Article in Chinese]

Author information

1
State Key Laboratory of Medical Virology & Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan 430071, China.

Abstract

OBJECTIVE:

To investigate the effects of epigallocatechin gallate (EGCG) against the influenza A virus in vitro and in vivo.

METHOD:

The cell culture technique was used in MDCK cells to get cell viability at different concentration of EGCG by MTT assay. Cytopathic effect (CPE) and MTT were applied to observe the protective function of EGCG and it's ingredients were administered to cells in three different ways (method I: administration before infection, method II: administration upon infection, and method II: administration after infection) to treat the infectious model in vitro. The anti-viral activity in vivo was performed on BALB/c mice, which were divided to receive EGCG. The mean survival days and the pulmonary pathological lesions of the infected mice were observed to evaluate the therapeutic efficacy of EGCG.

RESULT:

EGCG effectively inhibited influenza A virus in vitro. The death rate and pulmonary pathological lesions were decreased, and the mean survival days were prolonged by oral administration of EGCG in the mice infected by influenza A virus.

CONCLUSION:

EGCG has a strong effect against influenza A H1 N1 virus in vitro and in vivo, in a dose-dependent manner.

PMID:
19216171
[Indexed for MEDLINE]

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