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J Am Coll Cardiol. 2009 Feb 17;53(7):557-73. doi: 10.1016/j.jacc.2008.10.041.

Acute heart failure syndromes.

Author information

1
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Chicago, IL 60611, USA. m-gheorghiade@northwestern.ed

Abstract

Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and symptoms, neurohormonal, and renal abnormalities occurring soon after discharge may contribute to these high post-discharge event rates. Currently available assessment modalities combined with recent advances in cardiovascular therapies provide present-day opportunities to improve post-discharge outcomes. Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed. Improving post-discharge outcomes is the single most important goal in the management of acute heart failure syndromes.

PMID:
19215829
DOI:
10.1016/j.jacc.2008.10.041
[Indexed for MEDLINE]
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