Send to

Choose Destination
See comment in PubMed Commons below
Prog Mol Biol Transl Sci. 2009;85:467-500. doi: 10.1016/S0079-6603(08)00812-X.

mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems.

Author information

  • 1Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.


Escherichia coli contains a large number of suicide or toxin genes, whose expression leads to cell growth arrest and eventual cell death. One such toxin, MazF, is an ACA-specific endoribonuclease, termed "mRNA interferase."E. coli contains other mRNA interferases with different sequence specificities, which are considered to play important roles in growth regulation under stress conditions, and also in eliminating stress-damaged cells from a population. Recently, MazF homologues with 5-base recognition sequences have been identified, for example, those from Mycobacterium tuberculosis. These sequences are significantly underrepresented in the genes for protein families playing a role in the immunity and pathogenesis of M. tuberculosis. An mRNA interferase in Myxococcus xanthus is essential for programmed cell death during fruiting body formation. We propose that mRNA interferases play roles not only in cell growth regulation and programmed cell death, but also in regulation of specific gene expression (either positively or negatively) in bacteria.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center