Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurogastroenterol Motil. 2009 Feb;21(2):113-27. doi: 10.1111/j.1365-2982.2008.01256.x.

Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.

Author information

1
Department of Biology, Emory University, Atlanta, GA 30322, USA.

Abstract

The enteric nervous system (ENS) is the largest and most complicated subdivision of the peripheral nervous system. Its action is necessary to regulate many of the functions of the gastrointestinal tract including its motility. Whilst the ENS has been studied extensively by developmental biologists, neuroscientists and physiologists for several decades it has only been since the early 1990s that the molecular and genetic basis of ENS development has begun to emerge. Central to this understanding has been the use of genetic model organisms. In this article, we will discuss recent advances that have been achieved using both mouse and zebrafish model genetic systems that have led to new insights into ENS development and the genetic basis of Hirschsprung's disease.

PMID:
19215589
PMCID:
PMC4041618
DOI:
10.1111/j.1365-2982.2008.01256.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center