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Horm Metab Res. 2009 Feb;41(2):159-63. doi: 10.1055/s-0028-1119408. Epub 2009 Feb 12.

Wnt-signalling and the metabolic syndrome.

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Department of Endocrinology, Diabetes and Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany.


The Wnt-signalling pathway plays a well-established role in embryogenesis and tumourigenesis. However, recent data puts Wnt-signalling in the context of metabolic disease. In vitro and in vivo data characterised the role of Wnt-signalling molecules in the regulation of adipocyte differentiation (adipogenesis). Furthermore, Wnts play a pivotal role in regulating pancreatic beta-cell function and mass. In addition, studies found polymorphisms within the gene encoding TCF7L2, a Wnt-regulated transcription factor, to contribute an increased risk to develop type 2 diabetes mellitus in humans. This review will summarise recent aspects of Wnt-signalling in these pathophysiologic events and discuss the contributions of dysregulation in Wnt-signalling to features of the metabolic syndrome.

[Indexed for MEDLINE]

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