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Cancer Invest. 2009 Mar;27(3):264-72. doi: 10.1080/07357900802406319.

PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.

Author information

1
Department of Urology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells.

PMID:
19212833
PMCID:
PMC3086358
DOI:
10.1080/07357900802406319
[Indexed for MEDLINE]
Free PMC Article

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