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Bioorg Med Chem Lett. 2009 Mar 1;19(5):1349-56. doi: 10.1016/j.bmcl.2009.01.054. Epub 2009 Jan 22.

N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.

Abstract

Starting with a hit from vHTS attained by a docking procedure of virtual compounds into ATP pockets of different kinases applying the 4SCan technology, variations of the adenine mimic resulted in the identification of promising scaffolds, giving rise to in vitro IC(50) values in the nanomolar range on different kinases down to 63nM.

PMID:
19211246
DOI:
10.1016/j.bmcl.2009.01.054
[Indexed for MEDLINE]

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