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Curr Biol. 2009 Feb 10;19(3):R115-7. doi: 10.1016/j.cub.2008.12.019.

Selfish DNA: homing endonucleases find a home.

Author information

1
Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada. rwb@st-andrews.ac.uk

Abstract

Self-splicing group I introns come in two flavours - those with a homing endonuclease to promote mobility of the intron, and those without an endonuclease. How homing endonucleases and self-splicing introns associate to form a composite selfish genetic element is a question of long-standing interest. Recent work has revealed that a shared characteristic of both introns and endonucleases, the targeting of conserved sequences, may provide the impetus for the evolution of composite mobile genetic elements.

PMID:
19211047
DOI:
10.1016/j.cub.2008.12.019
[Indexed for MEDLINE]
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