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Genes Cells. 2009 Mar;14(3):435-44. doi: 10.1111/j.1365-2443.2009.01280.x. Epub 2008 Feb 6.

New model for assembly dynamics of bacterial tubulin in relation to the stages of DNA replication.

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National Institute of Genetics, Research Organization of Information and Systems, Mishima, Shizuoka 411-8540, Japan.


How living cells receive their genome through cell division has been one of the important questions of biology. In prokaryotes, cell division starts with formation of a ring-shaped microtubule-like structure, FtsZ-ring, at the potential division site. All the previous models suggested that FtsZ-ring is formed coupling to termination or far after initiation of DNA replication. In contrast, we demonstrated that a close communication with DNA replication is maintained throughout the cell cycle. FtsZ starts to assemble to the cell center coupling to initiation of DNA replication, and stabilizes as FtsZ-ring at its termination, but does not constrict before separation of nucleoids. This combination of a positive and a negative control would guarantee that a successful replication event would inevitably induce one cell division such that each of the daughter cells would receive one and only one daughter nucleoid.

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