Format

Send to

Choose Destination
See comment in PubMed Commons below
Twin Res Hum Genet. 2009 Feb;12(1):8-18. doi: 10.1375/twin.12.1.8.

Modeling extended twin family data I: description of the Cascade model.

Author information

1
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, United States of America. matthew.c.keller@gmail.com

Abstract

The classical twin design uses data on the variation of and covariation between monozygotic and dizygotic twins to infer underlying genetic and environmental causes of phenotypic variation in the population. By using data from additional relative classes, such as parents, extended twin family designs more comprehensively describe the causes of phenotypic variation. This article introduces an extension of previous extended twin family models, the Cascade model, which uses information on twins as well as their siblings, spouses, parents, and children to differentiate two genetic and six environmental sources of phenotypic variation. The Cascade also relaxes assumptions regarding mating and cultural transmission that existed in previous extended twin family designs. The estimation of additional parameters and relaxation of assumptions is potentially important, not only because it allows more fine-grained descriptions of the causes of phenotypic variation, but more importantly, because it can reduce the biases in parameter estimates that exist in earlier designs.

PMID:
19210175
PMCID:
PMC4070287
DOI:
10.1375/twin.12.1.8
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Cambridge University Press Icon for PubMed Central
    Loading ...
    Support Center