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Bioorg Med Chem Lett. 2009 Mar 1;19(5):1287-91. doi: 10.1016/j.bmcl.2009.01.073. Epub 2009 Feb 7.

Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.

Author information

1
Novartis Institutes for Biomedical Research, Neuroscience Disease Area, 4002 Basel, Switzerland.

Abstract

A novel class of alpha7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis gamma-lactam scaffold has been optimized to reveal highly potent and selective alpha7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice.

PMID:
19208472
DOI:
10.1016/j.bmcl.2009.01.073
[Indexed for MEDLINE]

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