Automatic identification of diabetic maculopathy stages using fundus images

J Med Eng Technol. 2009;33(2):119-29. doi: 10.1080/03091900701349602.

Abstract

Diabetes mellitus is a major cause of visual impairment and blindness. Twenty years after the onset of diabetes, almost all patients with type 1 diabetes and over 60% of patients with type 2 diabetes will have some degree of retinopathy. Prolonged diabetes retinopathy leads to maculopathy, which impairs the normal vision depending on the severity of damage of the macula. This paper presents a computer-based intelligent system for the identification of clinically significant maculopathy, non-clinically significant maculopathy and normal fundus eye images. Features are extracted from these raw fundus images which are then fed to the classifier. Our protocol uses feed-forward architecture in an artificial neural network classifier for classification of different stages. Three different kinds of eye disease conditions were tested in 350 subjects. We demonstrated a sensitivity of more than 95% for these classifiers with a specificity of 100%, and results are very promising. Our systems are ready to run clinically on large amounts of datasets.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Diabetic Retinopathy / diagnosis*
  • Diabetic Retinopathy / pathology
  • Diagnostic Imaging / methods
  • Exudates and Transudates / metabolism
  • Female
  • Fovea Centralis
  • Fundus Oculi
  • Humans
  • Image Enhancement / methods*
  • Macula Lutea / pathology*
  • Male
  • Middle Aged
  • Neural Networks, Computer
  • Normal Distribution
  • Pattern Recognition, Automated / methods*
  • Photography
  • Predictive Value of Tests
  • Sensitivity and Specificity