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Infect Immun. 2009 May;77(5):2184-92. doi: 10.1128/IAI.01455-08. Epub 2009 Feb 9.

Modulation of Toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus.

Author information

1
Department of Medicine (463), Radboud University Nijmegen Medical Center, P.O. Box 9101, Geert Grootplein 8, 6525 GA Nijmegen, The Netherlands.

Abstract

Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in human mononuclear cells with suppression of IL-1beta mRNA transcription. Background TLR2 and TLR4 mRNA transcription was not influenced. A. fumigatus conidia induced TLR2 internalization and uptake into the phagosome with a resultant decrease in surface receptor expression. A. fumigatus hyphae, on the other hand, selectively downregulated the TLR4-mediated response. These novel immunosuppressive effects may facilitate the invasiveness of A. fumigatus.

PMID:
19204090
PMCID:
PMC2681752
DOI:
10.1128/IAI.01455-08
[Indexed for MEDLINE]
Free PMC Article

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