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Cancer Lett. 2009 Jun 18;278(2):174-182. doi: 10.1016/j.canlet.2009.01.015. Epub 2009 Feb 8.

Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.

Author information

1
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
2
Department of Herbal Resources Research and Quality Control Team, Korea Institute of Oriental Medicine, 305-811 Daejeon, Republic of Korea.
3
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea; Center for Distributed Sensor Network Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea. Electronic address: imsh@gist.ac.kr.

Abstract

Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.

PMID:
19203831
DOI:
10.1016/j.canlet.2009.01.015
[Indexed for MEDLINE]

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